From the back of the core rulebook:
"Welcome to the Weird West!
Strap on your six-gun and saddle up, partner, because there's Hell to pay and the currency is hot lead!
The Tombstone Epitaph has always been filled with lurid tales of daring desperadoes and deadly drifters, but lately the West's most read tabloid claims there's something more sinister stalking the frontier's lonely plains: Monsters.
Fortunately, where there are monsters, there are heroes. Squint-eyed gunfighters, card chucking hexslingers, savage braves, and righteous padres have all answered the call. And if they fight hard enough, they might just discover the identity of the mysterious Reckoners some say are behind it all.
There's Hell on the High Plains, amigo. Gather up your posse, strap on your Peacemaker, and get ready to ride!
Deadlands: Reloaded is the setting and core rules book for the Weird West line. It includes new rules for shootouts at High Noon, new Edges, Hindrances, and powers, a savage change to melee damage, a complete history of the Weird West, and more creepy critters than you can throw a tomahawk at."